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Abstract
Genitourinary involvement is observed in approximately 2-20% of brucellosis cases and epididymo-orchitis is the most common form. It may imitate a tumor by causing a painless mass. A 20-year-old male was admitted to the hospital with a history of a painless testicular mass for one month. Scrotal Doppler ultrasonography revealed a nodular lesion in the right testis with indistinct margins, not completely distinguishable from tumor. Testicular tumor could not be excluded by radical inguinal orchiectomy. Non-necrotizing granulomatous orchitis was reported following a wide-range of histochemical investigation for differential diagnosis of lymphoma. After a Brucella tube agglutination test was found positive at 1/640 titer, a combination of doxycycline and rifampin was started. Brucellosis should be taken into consideration in differential diagnosis of nonspecific granulomatous orchitis in endemic regions, and particularly in cases in which a painless testicular mass with negative tumor markers is identified.