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Volume 28, Issue 2

Case Report

Cross Resistance to HCV NS3 Inhibitor Developing During Treatment With Peginterferon, Ribavirin and Telaprevir

Günay Tuncer-Ertem
Affiliations
  • Ankara Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
,
Murat Sayan
Affiliations
  • Kocaeli Üniversitesi, Araştırma ve Uygulama Hastanesi, Merkez Laboratuvarı, PCR Ünitesi, Kocaeli, Türkiye; Yakın Doğu Üniversitesi, Deneysel Sağlık Bilimleri Araştırma Merkezi, Lefkoşa, Kuzey Kıbrıs Türk Cumhuriyeti
,
Şirin Hekimoğlu
Affiliations
  • Ankara Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
,
Necla Tülek
Affiliations
  • Ankara Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
  • hepatitis C virus
  • telaprevir
  • treatment
  • viral drug resistance

Abstract

In this report, a patient with chronic hepatitis C who was null responder to peginterferon and ribavirin and also developed viral rebound in the twelfth week of combination treatment with telaprevir is presented. NS3 resistance analysis performed at the same week has shown sensitivity to paritaprevir but resistance to telaprevir, boceprevir and simeprevir. The resistance analysis may assist the selection of antiviral drugs especially in the chronic hepatitis C patients with virologic failure.  

  • 92-94
  • 10.5152/kd.2015.18
  • July 23, 2019
  • 2171
  • 748
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  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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