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Volume 22, Issue 2

Original Article

Evaluation of Tigecycline Susceptibility by E-Test® in Multidrug-Resistant Acinetobacter baumannii Isolates

Ferit Kuşçu
Affiliations
  • Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
,
D. Barış Öztürk
Affiliations
  • Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
,
E. Ediz Tütüncü
Affiliations
  • Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
,
Meral Uslu
Affiliations
  • Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
,
Yunus Gürbüz
Affiliations
  • Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
,
Gönül Gülen
Affiliations
  • Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
,
İrfan Şencan
Affiliations
  • Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
  • Acinetobacter baumannii
  • Etest
  • multidrug resistance
  • tigecycline

Abstract

Objective: Emergence of multidrug resistance among Acinetobacter spp. complicates treatment of serious infections due to these organisms. Tigecycline is a member of a new class of antimicrobials, the glycylcyclines. 

Methods: In this study, we evaluated the in vitro activity of tigecycline in 121 multidrug resistant (MDR) A. baumannii isolates by E-test® (AB Biodisk, Sweden). 

Results: Among these isolates, 96 (79%) were susceptible to tigecycline, 19 (16%) showed intermediate susceptibility and 6 (5%) were resistant. MIC50 and MIC90 were 1.5 and 4 µg/ml, respectively. Seventy four per cent of carbapenem resistant isolates were found to be susceptible to tigecycline. 

Conclusion: In conclusion, tigecycline may prove useful in treating infections due to MDR Acinetobacter species.

  • 48-51
  • July 23, 2019
  • 1966
  • 769
Download as PDF
  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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