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Volume 30, Issue 3

Case Report

Hepatitis B Virus (HBV) Reactivation Induced by Bortezomib Use and Autologous Bone Marrow Transplantation in a Patient Recovered From HBV Infection

Fatma Yılmaz Karadağ
Affiliations
  • İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İstanbul, Türkiye
,
Pınar Ergen
Affiliations
  • İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İstanbul, Türkiye
,
Erman Öztürk
Affiliations
  • Koç Üniversitesi Hastanesi, Hematoloji Kliniği, İstanbul, Türkiye
,
Özlem Aydın
Affiliations
  • İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İstanbul, Türkiye
  • bortezomib
  • haematopoietic stem cell transplantation
  • Hepatitis B virus reactivation
  • multiple myeloma

Abstract

In hematologic malignancy patients with HBsAg positivity, the risk of hepatitis B reactivation is high in cases of high dose use of corticosteroids, rituximab, chemotherapy agents belonging to the anthracycline group and stem cell transplantation. HBV reactivation has been reported in the literature generally in HBsAg-negative, anti-HBc IgG- and anti-HBs-positive lymphoma patients in case of stem cell transplantation or use of rituximab as a chemotherapeutic agent. There are publications that report cases of HBV reactivation in HBsAg-negative multiple myeloma patients who have recieved bortezomib and/or stem cell. In this article, we present a multiple myeloma case with full recovery from HBV infection developing an acute hepatitis due to HBV reactivation after bortezomib use and autologous bone marrow transplantation. Finally, it was successfully treated with lamivudine. It is aimed to draw attention to the fact that hepatitis B serologic markers should be closely monitored for possibility of reactivation of hepatitis in candidates of chemotherapy/stem cell transplantation recovering from HBV infection. 

Klimik Dergisi 2017; 30(3): 146-8.

Cite this article as: Yılmaz-Karadağ F, Ergen P, Öztürk E, Aydın Ö. [Hepatitis B reactivation induced by bortezomib use and autologous bone marrow transplantation in a patient recovered from hepatitis B virus infection]. Klimik Derg. 2017; 30(3): 146-8. Turkish.

  • 146-148
  • 10.5152/kd.2017.35
  • July 23, 2019
  • 2494
  • 746
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  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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