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Volume 29, Issue 3

Case Report

Hepatocellular Carcinoma in a Chronic Hepatitis B Patient With Suppressed Viral Replication

Murat Kutlu
Affiliations
  • Pamukkale Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Denizli, Türkiye
,
Selda Sayın-Kutlu
Affiliations
  • Pamukkale Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Denizli, Türkiye
,
Aslıgül Dünya-Erdal
Affiliations
  • Dokuz Eylül Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Tıbbi Onkoloji Bilim Dalı, İzmir, Türkiye
,
Kadir Ağladıoğlu
Affiliations
  • Pamukkale Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Denizli, Türkiye
  • hepatitis B virus
  • hepatocellular carcinoma
  • telbivudine

Abstract

Suppressing viral replication is the main intervention for prevention of hepatocellular carcinoma (HCC) development, which is one of the purposes of treatment of chronic hepatitis B. We report a case of HCC in a 73-year-old woman with chronic hepatitis B who was treated and whose viral replication was successfully suppressed with antiviral therapy. The patient had anti-HBe positivity and her viral load was 1.01×106 IU/mL. Telbivudine treatment led to a decrease of HBV DNA below the detection limit on the second month of the treatment. But her α-fetoprotein level increased (121 ng/L) on the 30th month of the treatment. Magnetic resonance imaging showed a mass compatible with HCC on the liver and a biopsy revealed HCC. She was treated with chemo-embolization. Although viral suppression is achieved in patients with chronic hepatitis B, follow-up and HCC screening should be done regularly in patients who have HCC risk factors such as thrombocytopenia and older age, as in this case.

  • 130-132
  • 10.5152/kd.2016.31
  • July 23, 2019
  • 2133
  • 673
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  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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