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Volume 25, Issue 1

Original Article

Investigation of Norovirus Infections in Immunosuppressed and Immunocompetent Adults Suffering from Diarrhea

Şeyma Dağcı-Yaprak
Affiliations
  • Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Gaziantep, Türkiye
,
Ayşen Bayram
Affiliations
  • Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Gaziantep, Türkiye
,
Mustafa Pehlivan
Affiliations
  • Gaziantep Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, Gaziantep, Türkiye
,
Fahriye Ekşi
Affiliations
  • Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Gaziantep, Türkiye
,
Handan Haydaroğlu-Şahin
Affiliations
  • Gaziantep Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, Gaziantep, Türkiye
  • ELİSA
  • immunosupression
  • Norovirus

Abstract

Objective: The aim of this study was to investigate the prevalence of norovirus infections in immunosuppressed patients and in immunocompetent adults suffering from diarrhea. 

Methods: Between January-June 2011, 94 patients with diarrhea receiving immunosuppressive therapy at the Hematology Clinic were investigated for norovirus infection. Ninety-four patients with diarrhea were selected as the control group. The norovirus antigen was investigated in fecal samples by ELISA. White blood cell (WBC) count, C-reactive protein (CRP), and creatinine levels in patient and control groups were determined. 

Results: A norovirus infection was detected in 36.2% (34/94) of immunosuppressed patients, and in 9.6% (9/94) of the control group. Norovirus infection was seen more frequently in immunosuppressed patients than immunocompetents (p=0.001). Mean WBC and CRP levels were found significantly higher in patients infected with the norovirus, however, the difference in creatinine levels was statistically insignificant. 

Conclusion: Noroviruses have been detected more frequently in immunosuppressed patients, compared to immunocompetent adults. We emphasize that, in order to prevent norovirus outbreaks, strict hand hygiene and environmental disinfection procedures should be applied in the clinical wards of immunosuppressed patients.

  • 10-13
  • 10.5152/kd.2012.04
  • July 23, 2019
  • 2146
  • 696
Download as PDF
  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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