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Volume 23, Issue 3

Case Report

Rhinocerebral Mucormycosis Treated with Posaconazole: A Case Report

Yusuf Ziya Demiroğlu
Affiliations
  • Başkent Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye
,
Tuba Turunç
Affiliations
  • Başkent Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye
,
Alper Nabi Erkan
Affiliations
  • Başkent Üniversitesi, Tıp Fakültesi, Kulak Burun ve Boğaz Hastalıkları Anabilim Dalı, Ankara, Türkiye
,
Özlem Alkan
Affiliations
  • Başkent Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Ankara, Türkiye
,
Hikmet Eda Alışkan
Affiliations
  • Başkent Üniversitesi, Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye
,
Şule Çolakoğlu
Affiliations
  • Başkent Üniversitesi, Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye
,
Hande Arslan
Affiliations
  • Başkent Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye
  • Mucormycosis
  • posaconazole
  • salvage therapy

Abstract

Mucormycosis is an angioinvasive disease with an acute onset, fatal and aggressive course, which is commonly seen in immunosuppressed patients. In this case report, a 55-year-old diabetic man with rhinocerebral mucormycosis who was admitted with fever, headache and periorbital cellulitis, was presented. Although liposomal amphotericin B was given for as long as 90 days after an endoscopic sinus surgery, the clinical picture showed progression without a clinical response. Therefore, oral posaconazole was prescribed. Posaconazole therapy enabled not only his survival but also his follow up on an outpatient basis. Posaconazole was prescribed during one year without any severe side effect and was well tolerated. As a result,  posaconazole is a safe drug that may be used as salvage  therapy in patients with mucormycosis refractory to liposomal amphotericin B treatment.

  • 130-133
  • 10.5152/kd.2010.34
  • July 23, 2019
  • 2260
  • 787
Download as PDF
  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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