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Abstract
Trueperella pyogenes (T. pyogenes), formerly known as Arcanobacterium pyogenes, is a bacterium typically infecting immunocompromised patients and those in contact with animals. Generally, it is sensitive to penicillin, ceftriaxone, and macrolides. We report an atypical prosthetic joint infection caused by T. pyogenes. Notably, the patient had no animal contact and was immunocompetent. Moreover, the infection did not respond to beta-lactam antibiotics but was successfully treated with glycopeptides. This case highlights unusual features of T. pyogenes infection and emphasizes the importance of considering alternative antibiotic therapies in similar cases.