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Volume 38, Issue 1

Case Report

A Rare Clinical Finding in Epstein-Barr Virus Infection: Hoagland Sign

Merve Arslan
Affiliations
  • Çankırı Devlet Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Polikliniği, Çankırı, Türkiye
https://orcid.org/0000-0002-4191-0145
,
İrfan Akaray
Affiliations
  • Çankırı Devlet Hastanesi, Göz Hastalıkları Polikliniği, Çankırı, Türkiye
https://orcid.org/0000-0002-3872-9214
,
Mehmet Akyürek
Affiliations
  • Çankırı Devlet Hastanesi, Dermatoloji Polikliniği, Çankırı, Türkiye
https://orcid.org/0000-0003-0349-5531
  • Epstein-Barr virüs
  • Hoagland sign
  • İnfeksiyöz mononükleoz

Abstract

The Epstein-Barr virus (EBV) infection is an infectious disease characterized by clinical manifestations such as fever, pharyngitis, and painful cervical lymphadenopathy. It is a common cause of infectious mononucleosis, particularly observed in young adults. Bilateral painless swelling of the upper eyelids is a rare finding in EBV infection and is known as the “Hoagland sign.” Our case is noteworthy due to the incidence of the Hoagland sign and underscores the importance of considering EBV mononucleosis in the differential diagnosis.

Show References

References

  1. Hoagland RJ. Infectious mononucleosis. Am J Med. 1952;13(2):158-71. [CrossRef]
  2. Bronz G, Zanetti BPESM, Bianchetti MG, Milani GP, Lava SAG, Neuhaus TJ, et al. Bilateral upper eyelid swelling (Hoagland sign) in Epstein-Barr infectious mononucleosis: prospective experience. Infection. 2023;51(2):471-4. [CrossRef]
  3. Ricardo D. A protracted course of periorbital oedema in infectious mononucleosis caused by Epstein-Barr virus. Infect Dis Rep. 2022;14(6):942-5. [CrossRef]
  4. Sawant S. Hoagland sign: An early manifestation of acute infectious mononucleosis-A case report. Current Pediatric Research. 2017; 21(3):400-2.
  • 59-61
  • Merve Arslan
  • mrvdrarslan102526@gmail.com
  • 10.36519/kd.2024.4658
  • May 25, 2023
  • December 21, 2024
  • March 21, 2025

  • Arslan M, Akaray İ, Akyürek M. [A rare clinical finding in Epstein-Barr virus infection: Hoagland Sign]. Klimik Derg. 2024;37(4):59-61. Turkish.
  • 80
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  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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