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Volume 32, Issue 3

Original Article

Cardiovascular Risk Assessment and Relationship of Risk With Triglyceride/High Density Lipoprotein Cholesterol Ratio in HIV-Infected Patients

Ezgi Gülten
Affiliations
  • Ankara Numune Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
,
Başak Dokuzoğuz
Affiliations
  • Ankara Numune Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye
  • Cardiovascular disease risk
  • HIV
  • trigliserid

Objective: There isn't a widely accepted reference method to measure the cardiovascular disease (CVD) risk in human immunodeficiency virus (HIV)-infected patients. In our study, we aimed to investigate the presence of a parameter that would provide insight into CVD risk in HIV-positive individuals and can be conveniently used in their follow-up.

Methods: This retrospective observational study included 160 HIV-infected adults who were followed between 1 January 1996 and 1 June 2017. CVD risk factors and newly developing CVDs during the follow-up of these patients were recorded. By using the Framingham 10-year general CVD risk score (FRS-CVD-10) and American College of Cardiology/American Heart Association risk estimation (ACC/AHA CVDRS), patients’ CVD risks at initial and current evaluation were calculated. The association between these calculated values and factors that might be related to CVD risk were investigated.

Results: Of all patients, 82.5% were male and the mean age was 40.06 years. 68.2% of the patients were smokers and 92% had dyslipidemia. It was observed that 25% of the patients who completed the 113-month follow-up developed CVD. 37.1% and 39.4% of the patients were determined to be at high risk in terms of developing CVD according to FRS-CVD-10 and ACC/AHA CVDRS, respectively. Triglyceride to high density lipoprotein cholesterol ratio (Tg/HDL-c) was found to be higher in patients who developed CVD during follow-up and in those with high CVD risk scores. The positive predictive value of change in Tg/HDL-c ratio at the end of the first year in determining the CVD risk was 91.4% when FRS-CVD-10 was accepted as the reference test.

Conclusions: It was concluded that Tg/HDL-c ratio was a simple, inexpensive and reliable variable which demonstrated the increased risk of CVDs in HIV-infected patients. 

Klimik Dergisi 2019; 32(3): 285-91.

Cite this article as: Gülten E, Dokuzoğuz B. [Cardiovascular risk assessment and relationship of risk with triglyceride/high density lipoprotein cholesterol ratio in HIV-infected patients]. Klimik Derg. 2019; 32(3): 285-91. Turkish.

  • 285-291
  • 10.5152/kd.2019.76
  • December 27, 2019
  • 1937
  • 611
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  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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