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Volume 29, Issue 1

Case Report

Methotrexate Intoxication and Systemic Herpes Simplex Virus Infection in a Kidney Transplant Patient With Seronegative Arthropathy

Cihan Yeşil
Affiliations
  • Akdeniz Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Antalya, Türkiye
,
İmran Sağlık
Affiliations
  • Akdeniz Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Antalya, Türkiye
,
Ece Ulukal
Affiliations
  • Akdeniz Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Antalya, Türkiye
,
Ayça Gümüş
Affiliations
  • Akdeniz Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Antalya, Türkiye
,
Melike Cengiz
Affiliations
  • Akdeniz Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Antalya, Türkiye
,
Dilek Çolak
Affiliations
  • Akdeniz Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Antalya, Türkiye
,
Filiz Günseren
Affiliations
  • Akdeniz Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Antalya, Türkiye
  • HSV viremia
  • kidney transplantation
  • methotrexate

Abstract

Herpes simplex virus (HSV) 1 commonly causes local skin infection around the mouth and face. However, infection may become widespread and can be more severe especially in people with immunodeficiency. Methotrexate is an antiproliferative and antifolate drug which is used successfully in the treatment of chronic inflammatory diseases such as rheumatoid arthritis. On the other hand, it is associated with severe toxicity and side effects. In this article, a 53-year-old patient who applied to our hospital due to the rashes all over the body and apparent around the mouth, beside fever is presented. The patient who has been receiving methotrexate treatment because of rheumatoid arthritis had kidney transplantation five years ago. HSV 1 viremia was detected in the patient and the symptoms improved quickly with acyclovir. 

  • 43-46
  • 10.5152/kd.2016.10
  • July 23, 2019
  • 2906
  • 885
Download as PDF
  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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