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Volume 23, Issue 2

Case Report

Pulmonary Tuberculosis Following the Use of Infliximab

Nail Özgüneş
Affiliations
  • Göztepe Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İstanbul, Türkiye
,
Tuba Zengin-Elbir
Affiliations
  • Göztepe Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İstanbul, Türkiye
,
Saadet Yazıcı
Affiliations
  • Göztepe Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İstanbul, Türkiye
  • fever
  • Infliximab
  • pulmonary tuberculosis
  • tumor necrosis factorα

Abstract

Infliximab is a chimeric anti-tumor necrosis factor (TNF) agent used in the treatment of rheumatological diseases. Its potential side effects are infusion reactions, autoimmune diseases, malignancies, tuberculosis, and other infections. Several worldwide guidelines recommend prophylaxis for tuberculosis in high-risk patients, concomitant with infliximab usage. Although prophylaxis is protective in most cases, active tuberculosis can sometimes be seen. In Turkey, the duration of recommended and applied isoniazid regimens range from 6 to 12 months. Here, we report a case of lung tuberculosis which developed  two months after cessation of a 9-month INH prophylaxis in a 26-year-old man with ocular Behçet’s disease receiving infliximab treatment. This case highlights the necessity of close monitoring of tuberculosis in patients who undergo infliximab treatment.   

  • 70-72
  • 10.5152/kd.2010.21
  • July 23, 2019
  • 1984
  • 795
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  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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