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Volume 34, Issue 1

Original Article

Antibiotic Resistance in Pseudomonas aeruginosaIsolated from Hospital and Community-Acquired Infections: Current Status in Northern Cyprus

Buket Baddal
Affiliations
  • Yakın Doğu Üniversitesi, Tıbbi Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Lefkoşa, Kuzey Kıbrıs Türk Cumhuriyeti
https://orcid.org/0000-0003-3319-2179
,
Emrah Güler
Affiliations
  • Yakın Doğu Üniversitesi, Tıbbi Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Lefkoşa, Kuzey Kıbrıs Türk Cumhuriyeti
https://orcid.org/0000-0002-1635-0051
,
Kaya Süer
Affiliations
  • Yakın Doğu Üniversitesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Lefkoşa, Kuzey Kıbrıs Türk Cumhuriyeti
https://orcid.org/0000-0002-2565-3425
  • infections
  • microbial drug resistance
  • Pseudomonas aeruginosa
  • Turkish Republic of Northern Cyprus

Abstract

Objective: Pseudomonas aeruginosa is among the most common nosocomial opportunistic pathogens capable of acquiring multi-drug resistance. Recent data on antibiotic resistance in Northern Cyprus is limited. We aimed evaluate antibiotic susceptibility profiles of P. aeruginosa strains isolated from clinical samples and contribute to the update of antibiotic use policies in the country.

Methods: Total of 504 P. aeruginosa strains sent to Microbiology Laboratory from various clinics from September 2016 to October 2019 were retrospectively analyzed. Clinical samples were cultured on %5 sheep blood agar and eosin-methylene blue agar. BD Phoenix™ 100 (Becton Dickinson Co., Sparks, Maryland, USA) automated bacterial identification system and conventional antimicrobial susceptibility testing was used. Antimicrobial susceptibility was determined in accordance with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines. The distribution of P. aeruginosa isolates according to hospital services, sample types, admission types, age group, and antibiotic resistance rates were investigated.

Results: P. aeruginosa was mostly isolated from urine (37.3%), deep tracheal aspirate (17.9%) and abscess/wound material (17.9%) samples. Strains were most commonly obtained from the intensive care clinics (35.9%). Infections were observed mainly in >65 age group (49.6%) and in-patients (70.8%) group. Antibiotic resistance rates were detected as 47.7% for aztreonam, 32% for cefepime, 26.3% for ceftazidime, 26.4% for imipenem, 25.6% for ciprofloxacin, 24.6% for meropenem, 19.7% for piperacillin-tazobactam, 13.5% for gentamicin, 12.2% for colistin and 5.3% for amikacin. Multi-drug resistant P. aeruginosa rate was 19.2%. When compared with 2010-2014, a substantial increase in rates of cefepime, ceftazidime, ciprofloxacin, piperacillin-tazobactam and carbapenem resistance was detected within the last three years.

Conclusions: In this study, the highest resistance rates were detected against aztreonam and cefepime, and the highest susceptibility was observed for colistin and amikacin. These results may be used for empirical treatments, establishment of rational antibiotic use policies and prevention of emerging antibiotic resistance problem in Cyprus.

  • 31-6
  • Buket Baddal
  • [email protected]
  • 10.36519/kd.2021.06
  • March 19, 2020
  • February 15, 2021
  • April 30, 2021

  • Buket B, Güler E, Süer K. [Antibiotic resistance in Pseudomonas aeruginosa isolated from hospital and community-acquired infections: Current status in Northern Cyprus]. Klimik Derg. 2021; 34(1): 31-6. Turkish.
  • 768
  • 302
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  • This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. CC BY-NC
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